Cancer stem-like cells (CSCs) have been reported to play major roles in tumorigenesis, tumor relapse, and metastasis after therapy against colorectal carcinoma (CRC).Therefore, identification of colorectal CSC regulators could provide promising targets for CRC.Ligand-of-Numb protein X1 (LNX1) is one E3 ubiquitin ligase which mediates the ubiquitina
Pseudobulbar affect (PBA) is associated with several neurological diseases and is underrecognized in clinical practice; however, PBA symptoms are often attributed to psychiatric or mood disorders rather than to neurological etiology.Until recently, there were no US Food and Drug Administration therapies approved for treating this condition, SPORT B
A major concern for the Australian grain industry in recent years is the constant threat of resistance to the key disinfestant phosphine in a range of stored grain pests.The need to maintain the usefulness of phosphine and to contain the development of resistance are critical to international market access for Australian grain.Strong levels of resi
Cancer cells resist the immune response in a process known as immune editing or immune evasion.Therapies that target the immune system have revolutionized cancer treatment; however, immunotherapies have been ineffective for the majority of ovarian cancer cases.In this issue of the JCI, Chen, Xie, et al.hypothesized that hypomethylating agent (HMA)